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KMID : 0385219920020020111
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Korean Journal of Gerontology
1992 Volume.2 No. 2 p.111 ~ p.117
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Changes in Oxidative Status and Antioxidant Activity of Rat Skin Homogenates with Age
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Choi Kee-Oh
Son Se-Ho
Lee Min-Hwa
Kim Young-Pyo
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Abstract
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The effects of aging on lipid peroxidation, protein oxidation, and antioxidant activity of skin homogenates were investigated in male Sprague-Dawley rats at 3 and 12 months of age. Lipid peroxidation of skin homogenates decreased with age, but protein oxidation increased with age. Superoxide dismutase activity decreased to 60% in 12 month-old rats and catalase activity showed no change with age, but glutathione peroxidase activity to 127% in 12 month-old rats. -Tocopherol, a major antioxidant in biomembranes, and reduced glutathione (GSH) did not show a statistically significant change, but the GSH/GSSG ratio was 1.5 times higher in 12 month-old rats than was in 3 month-old rats. The above results suggest that the age-related increase in protein oxidation is due to the decrease in superoxide dismutase activity and that the age-related decrease in lipid peroxidation is due to the increase in glutathione peroxidase activity and GSH/GSSG ratio.
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KEYWORD
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lipid peroxidation, protein oxidation, antioxidants, rat skin homogenates, age
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